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A first clue came in 1986 when a morphologically similar but antigenically distinct virus was found to cause AIDS in patients in western Africa (Clavel et al. Curiously, this new virus, termed human immunodeficiency virus type 2 (HIV-2), was only distantly related to HIV-1, but was closely related to a simian virus that caused immunodeficiency in captive macaques (Chakrabarti et al. Known examples of cross-species transmissions, as well as the resulting viruses, are highlighted in red. The evolutionary relationships among Pol sequences (∼ 770 amino acids) derived from various mammalian lentiviruses; host species are indicated at the right.
Sub-Saharan Africa, which includes South Africa and every other country south of the Sahara Desert, has the most severe HIV-AIDS epidemic in the …
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